|
KMID : 1161420230260040270
|
|
Journal of Medicinal Food
2023 Volume.26 No. 4 p.270 ~ p.274
|
|
|
Scopoletin Improves Glucose Homeostasis in the High-Fructose High-Fat Diet?Induced Diabetes Model in Wistar Rats
|
|
Gurpreet Kaur Batra
Aishwarya Anand
Swati Sharma
Sheetal Sharma
Shobhit Bhansali
Amol N. Patil
|
|
|
Abstract
|
|
|
|
Antihyperglycemic action of scopoletin needs to be validated before considering it for clinical trials. The present study explored antihyperglycemic action of scopoletin in high-fructose high-fat diet (HFHFD)?induced diabetes in rats. The animal study was performed using 48 rats, 6 in each group. HFHFD was administered for model induction for 74 days. Rats in Group I (normal control [NC]) and group II (experimental control [EC]) received normal saline and HFHFD, respectively, throughout the study. Groups III, IV, V, and VI received oral scopoletin (1?mg/kg [low dose, LD], 5?mg/kg [medium dose, MD], 10?mg/kg [high dose, HD]), and metformin (250?mg/kg; positive control [PC] for efficacy), respectively, once daily from day 60 to 74, in addition to HFHFD. Group VII (10?mg/kg oral scopoletin safety group) and VIII (0.1?mg/kg oral warfarin; PC for safety) were separately used for bleeding time-clotting time (BTCT) assessment on days 60, 68, and 74. Groups I, VII, and VIII rats were studied for safety assessment. Later, animals were sacrificed for histological examination. Scopoletin-treated groups showed a significant decline in glucose levels, especially in the MD (5.18?±?0.12) and HD group (5.271?±?0.11) in comparison to the EC (6.37?±?0.05) on day 74 (P??.05). The study showed that scopoletin dose-independently reversed insulin resistance. Consequently, scopoletin can be a potential candidate for antidiabetic drug development.
|
|
|
KEYWORD
|
|
|
anticoagulant action, antihyperglycemic, beta cell function, high fructose high-fat diet, homeostasis model assessment, insulin resistance, scopoletin
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|